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Stepan B. Melnyk, M.D., Ph.D.

Picture of Picture ofStepan B. Melnyk
  • Associate Professor, College of Medicine, Department of Pediatrics


  • Developmental Pediatrics


  • Basic Scientist

Contact Information

  • Email:
    Phone: 501-364-4659
    Address: Arkansas Children's Hospital
    1 Children's Way
    Little Rock, AR 72202


  • Ph.D., Lviv Medical University, 1994
  • Ivano-Frankivsk Medical College, 1981
  • MD, Ivano-Frankivsk Medical University, 1990


  • Researcher Fellow, Molecular Biology, National Center for Toxicological Research, 1996-1999

Clinical & Research Interests

  • Basic Science, Oxidative stress biomarkers in pediatric pathology

Recent Publications

  • Journal Article, Heard ME., Simmen FA., Yang Y., Pabona JM., Simmen RC., Melnyk S. High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated with Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status.. Endocrinology. 2016 May 13 2016 May 13;
  • Journal Article, Montales MTE., Melnyk SB., Liu SJ., Simmen FA,., Simmen RC. Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice.. Endocrine-Related Cancer 2016 June 21;
  • Journal Article, Sridharan V., Thomas CJ., Cao M., Melnyk SB., Pavliv O., Joseph J., Singh SP., Sharma S., Moros EG., Boerma M. Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart. Radiother Oncol. 2016 May; 119(2):259-64.
  • Journal Article, Frye RE., Delhey L., Slattery J,., Tippett M ., Wynne R., Rose S., Kahler SG., Bennuri SC., Melnyk S., Sequeira JM., Quadros E. Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups.. Front Neurosci. 2016 March 9; 9(10):80.
  • Journal Article, Koturbash I., Miousse IR., Sridharan V., Nzabarushimana E., Skinner CM., Melnyk SB., Pavliv O., Hauer-Jensen M., Nelson GA., Boerma M. Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.. Mutat Res. 2016 May; 787:43-53.
  • Journal Article, Blossom SJ., Melnyk SB., Li M., Wessinger WD., Cooney CA. Inflammatory and oxidative stress-related effects associated with neurotoxicity are maintained after exclusively prenatal trichloroethylene exposure.. Neurotoxicology 2016 January 23;
  • Journal Article, Lu X., Miousse IR., Pirela SV., Moore JK., Melnyk S., Koturbash I., Demokritou P. In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles.. Nanotoxicology 2016 January; 5(10):629-39.
  • Journal Article, Lu X., Miousse IR., Pirela SV., Melnyk S., Koturbash I., Demokritou P. Short-term exposure to engineered nanomaterials affects cellular epigenome. Nanotoxicology 2016 10(2):140-50.
  • Journal Article, Kovalchuk A., Rodriguez-Juarez R., Ilnytskyy Y., Byeon B., Shpyleva S., Melnyk S., Pogribny I., Kolb B,., Kovalchuk O. Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connection. Aging 2016 April; 8(4):697-711.
  • Journal Article, Yoo HS., Cichocki JA., Kim S., Venkatratnam A., Iwata Y., Kosyk O., Bodnar W., Sweet S., Knap A., Wade T., Campbell J., Clewell HJ., Melnyk SB, Chiu WA, Rusyn I. The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.. Toxicol Sci. 2015 October; 147(2):339-49.

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